GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9309473 | 1 | rs10189574 | chr2:73698518 | ALMS1P | chr2:73872046-73912692:+ | 0.58 | 4.72 | 8.0E-6 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs10190219 | chr2:73658331 | ALMS1P | chr2:73872046-73912692:+ | 0.63 | 4.71 | 8.5E-6 | Metabolite levels |
| THYM | cis | rs3820928 | 1 | rs10193316 | chr2:227777650 | RHBDD1 | chr2:227700773-227861591:+ | -0.31 | -4.54 | 1.67E-5 | Pulmonary function |
| THYM | cis | rs60843830 | 1 | rs10193373 | chr2:281886 | SH3YL1 | chr2:218138-264810:- | -0.34 | -4.91 | 3.83E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs3820928 | 1 | rs10193404 | chr2:227777757 | RHBDD1 | chr2:227700773-227861591:+ | -0.31 | -4.51 | 1.82E-5 | Pulmonary function |
| THYM | cis | rs9309473 | 1 | rs10193972 | chr2:73717656 | ALMS1P | chr2:73872046-73912692:+ | 0.58 | 4.75 | 7.12E-6 | Metabolite levels |
| THYM | cis | rs7565981 | 1 | rs10194962 | chr2:101418410 | PDCL3 | chr2:101179418-101193201:+ | 0.55 | 4.47 | 2.15E-5 | Creutzfeldt-Jakob disease (variant) |
| THYM | cis | rs3820928 | 1 | rs10197757 | chr2:227763244 | RHBDD1 | chr2:227700773-227861591:+ | -0.32 | -4.77 | 6.67E-6 | Pulmonary function |
| THYM | cis | rs3820928 | 1 | rs10204368 | chr2:227774244 | RHBDD1 | chr2:227700773-227861591:+ | -0.31 | -4.56 | 1.54E-5 | Pulmonary function |
| THYM | cis | rs9309473 | 1 | rs10207220 | chr2:73785046 | ALMS1P | chr2:73872046-73912692:+ | 0.59 | 4.53 | 1.69E-5 | Metabolite levels |
| THYM | cis | rs3820928 | 1 | rs10210763 | chr2:227776029 | RHBDD1 | chr2:227700773-227861591:+ | -0.31 | -4.56 | 1.54E-5 | Pulmonary function |
| THYM | cis | rs9815354 | 1 | rs10212536 | chr3:41827026 | ULK4 | chr3:41288091-42003660:- | 1 | 10.48 | 1.54E-17 | Diastolic blood pressure |
| THYM | cis | rs2294008 | 1 | rs10216533 | chr8:143763690 | PSCA | chr8:143761875-143764142:+ | 0.43 | 4.29 | 4.22E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| THYM | cis | rs10218795 | 1 | rs10218795 | chr1:145416056 | NOTCH2NL | chr1:145209111-145295525:+ | 0.88 | 5.72 | 1.21E-7 | Coronary heart disease |
| THYM | cis | rs4294134 | 1 | rs10234309 | chr7:135311167 | PL-5283 | chr7:135347221-135378160:+ | 0.36 | 5.03 | 2.33E-6 | Paget's disease |